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Hydrogel Nanoparticles with Covalently Linked Coomassie Blue for Brain Tumor Delineation Visible to the Surgeon

By Guochao Nie, Hoe Jin Hah, Gwangseong Kim, Yong‐eun Koo Lee, Ming Qin, Tanvi S. Ratani, Panagiotis Fotiadis, Amber Miller, Akiko Kochi, Di Gao, Thomas Chen, Daniel A. Orringer, Oren Sagher, Martin A. Philbert and Raoul Kopelman

Abstract

Delineation of tumor margins is a critical and challenging objective during brain cancer surgery. A tumor‐targeting deep‐blue nanoparticle‐based visible contrast agent is described, which, for the first time, offers in vivo tumor‐specific visible color staining. This technology thus enables color‐guided tumor resection in real time, with no need for extra equipment or special lighting conditions. The visual contrast agent consists of polyacrylamide nanoparticles covalently linked to Coomassie Blue molecules (for nonleachable blue color contrast), which are surface‐conjugated with polyethylene glycol and F3 peptides for efficient in vivo circulation and tumor targeting, respectively. Hydrogel nanoparticles containing a high concentration of visible dye by covalent linkage, with PEGylated surface and conjugated tumor targeting moiety, enable visual delineation of brain tumors in vitro and in vivo. This technology enables color‐guided tumor resection in real time, with no need for extra equipment or special lighting conditions

Publisher: WILEY‐VCH Verlag
Year: 2012
DOI identifier: 10.1002/smll.201101607
OAI identifier: oai:deepblue.lib.umich.edu:2027.42/90550
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