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Synthesis of [ 18 F]fluoroethoxy‐benzovesamicol, a radiotracer for cholinergic neurons

By G. Keith Mulholland, Yong‐woon Jung, Donald M. Wieland, Michael R. Kilbourn and David E. Kuhl

Abstract

Full experimental details are given for the preparation of [ 18 F]fluoroethoxy‐benzovesamicol, (−)‐( 2R, 3R )‐ trans ‐2‐hydroxy‐3‐(4‐phenylpiperidino)‐5‐(2‐[ 18 F]fluoroethoxy)‐1,2,3,4‐tetralin, a new fluorine‐18 labeled cholinergic neuron mapping agent for use in positron emission tomography (PET). This radiotracer was made by nucleophilic radiofluorination of tosyloxyethoxy‐benzovesamicol, followed by reverse phase HPLC purification, in decay corrected radiochemical yield exceeding 60%

Publisher: John Wiley & Sons, Ltd.
Year: 1993
DOI identifier: 10.1002/jlcr.2580330704
OAI identifier: oai:deepblue.lib.umich.edu:2027.42/90363
Journal:

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