Highlighting the versatility of the tracerlab synthesis modules. Part 1: fully automated production of [ 18 F]labelled radiopharmaceuticals using a Tracerlab FX FN

Abstract

The field of radiochemistry is moving toward exclusive use of automated synthesis modules for production of clinical radiopharmaceutical doses. Such a move comes with many advantages, but also presents radiochemists with the challenge of re‐configuring synthesis modules for production of radiopharmaceuticals that require nonconventional radiochemistry while maintaining full automation. This review showcases the versatility of the Tracerlab FX FN synthesis module by presenting simple, fully automated methods for producing [ 18 F]FLT, [ 18 F]FAZA, [ 18 F]MPPF, [ 18 F]FEOBV, [ 18 F]sodium fluoride, [ 18 F]fluorocholine and [ 18 F]SFB. Copyright © 2011 John Wiley & Sons, Ltd. The versatility of the Tracerlab‐FX FN synthesis module is showcased through preparation of a range of [ 18 F]labeled radiopharmaceuticals. Each radiopharmaceutical is prepared using a unique radiochemical strategy and all reported syntheses are fully automated. Copyright © 2011 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86935/1/1865_ftp.pd