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Suppression of mitogen-induced lymphocyte proliferation by syringomycin-E

By Vijendra K. Singh and Jon Y. Takemoto


Syringomycin E (SR-E) is low molecular weight bacterial lipodepsipeptide with antifungal properties. Owing to immunosuppressive activities of such compounds as cyclosporine, FK506 and rapamycin, we studied the effect of SR-E on proliferation of human blood lymphocytes in vitro. SR-E, by itself, had no effect but the mitogen-induced lymphocyte proliferation was significantly suppressed. The suppressive effect was more pronounced with pokeweed mitogen (PWM) as compared to phytohemagglutinin (PHA) or monoclonal antibody to CD3 (anti-CD3). Since these mitogens induce cellular immunity (T cell-dependent), SR-E may potentially be a novel immunosuppressive compound

Publisher: Blackwell Publishing Ltd
Year: 1996
DOI identifier: 10.1111/j.1574-695X.1996.tb00069.x
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