oaioai:deepblue.lib.umich.edu:2027.42/74267

Suppression of mitogen-induced lymphocyte proliferation by syringomycin-E

Authors
Publication date
1 September 1996
Publisher
Blackwell Publishing Ltd
Doi

    Abstract

    Syringomycin E (SR-E) is low molecular weight bacterial lipodepsipeptide with antifungal properties. Owing to immunosuppressive activities of such compounds as cyclosporine, FK506 and rapamycin, we studied the effect of SR-E on proliferation of human blood lymphocytes in vitro. SR-E, by itself, had no effect but the mitogen-induced lymphocyte proliferation was significantly suppressed. The suppressive effect was more pronounced with pokeweed mitogen (PWM) as compared to phytohemagglutinin (PHA) or monoclonal antibody to CD3 (anti-CD3). Since these mitogens induce cellular immunity (T cell-dependent), SR-E may potentially be a novel immunosuppressive compound.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74267/1/j.1574-695X.1996.tb00069.x.pd

    Similar works

    Full text

    thumbnail-image

    Deep Blue Documents at the University of Michigan

    redirect
    oaioai:deepblue.lib.umich.edu:202...
    Last time updated on 25/05/2012

    This paper was published in Deep Blue Documents at the University of Michigan.

    Having an issue?

    Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.