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Gene Transfer In Vivo with DNA–Liposome Complexes: Lack of Autoimmunity and Gonadal Localization

By Elizabeth G. Nabel, David Gordon, Zhi-Yong Yang, Ling Xu, Hong San, Gregory E. Plautz, Bei-Yue Wu, Xiang Gao, Leaf Huang and Gary J. Nabel

Abstract

Overview summary The use of DNA–liposome complexes to transfer genes in vivo is now underway in an active clinical protocol. Mouse safety and acute toxicity data have been published previously (Hum. Gene Ther. 3, 267–275). In the present paper, Nabel et al. begin to provide long-term safety data, specifically with regard to the potential for autoimmune damage to major organs or for the transfer of the foreign genes into reproductive tissue

Publisher: Mary Ann Liebert, Inc., publishers
Year: 1992
DOI identifier: 10.1089/hum.1992.3.6-649
OAI identifier: oai:deepblue.lib.umich.edu:2027.42/63110
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