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Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene

By Kunliang Guan, Lynn Farh, Tricia K. Marshall and Robert J. Deschenes

Abstract

The isolation and characterization of MGM1 , and yeast gene with homology to members of the dynamin gene family, is described. The MGM1 gene is located on the right arm of chromosome XV between STE4 and PTP2 . Sequence analysis revealed a single open reading frame of 902 residues capable of encoding a protein with an approximate molecular mass of 101 kDa. Loss of MGM1 resulted in slow growth on rich medium, failure to grow on non-fermentable carbon sources, and loss of mitochondrial DNA. The mitochondria also appeared abnormal when visualized with an antibody to a mitochondrial-matrix marker. MGM1 encodes a dynamin-like protein involved in the propagation of functional mitochondria in yeast

Publisher: Springer-Verlag
Year: 1993
DOI identifier: 10.1007/BF00324678
OAI identifier: oai:deepblue.lib.umich.edu:2027.42/46976
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