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Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers

By Trevor Robbins, Charles R. Schuster, Michael R. Kilbourn, Gantt P. Galloway, John Roll, Leslie H. Lundahl, Pamela Keenan, Robert A. Koeppe, Chris-Ellyn Johanson, Kirk A. Frey and Nancy Lockhart


Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have suggested similar effects and correlated motor and cognitive deficits. The present study was designed to further our understanding of changes in brain function in humans that might result from chronic high dose use of MA after at least 3 months of abstinence

Publisher: Springer-Verlag
Year: 2006
DOI identifier: 10.1007/s00213-006-0330-6
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