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Experimental variables in the effects of postsession injections of strychnine sulphate on a classically conditioned response

By James D. Papsdorf and Charles F. Levinthal


Postsession strychnine injections have been shown to retard acquisition rates of the classically conditioned nictitating membrane response (CCNMR) of rabbits trained at a CS-US interval of 1000 msec. The particular interval value employed in CCNMR acquisition was found to be important in the magnitude of the postsession strychnine effect. Strychnine Ss trained at a CS-US interval=1250 msec (nonoptimal) were significantly depressed in acquisition rates relative to saline controls, while strychnine Ss trained at a CS-US interval=250 msec (optimal) were not. Interpretations are based upon the presumed effects of CNS excitants on memory consolidation and possible neurological correlates of the CS-US interval parameter

Publisher: Springer-Verlag
Year: 1970
DOI identifier: 10.1007/BF00402096
OAI identifier: oai:deepblue.lib.umich.edu:2027.42/46356
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