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EEG spectral power and mean frequencies in early heroin abstinence

By Anna G. Polunina and Dmitry M. Davydov


The purpose of the present study was to investigate cumulative heroin effects on brain functioning by studying relationships between EEG spectral power and mean frequencies and heroin abusing history. Eyes closed resting EEG data were collected from the 19 monopolar electrode sites in 33 heroin abusers and 13 age-matched healthy volunteers. The mean age of the patients was 23.1±4.5, the duration of daily heroin abuse (DDHA) ranged from 4 to 44 months, the i.v. doses of heroin ranged from 0.04 to 1.00 g/day, the abstinence length ranged from 6 days to 4.5 months. GLM repeated measures procedure revealed a significant group effect on the distribution of the mean power spectrum between bands and mean frequencies in almost all analyzed derivations. Further analysis demonstrated that these intergroup differences were diversely related to at least three aspects of heroin taking history. Frequency shifts in alpha2 range, most prominent in frontal and central derivations, were related to duration of daily heroin consumption. Slowing of alpha1 mean frequency, most prominent in central, temporal and occipital derivations, was registered mainly in heroin addicts who abused high doses of the drug. Spectral power characteristics of brain electrical activities in our patient population were strongly predicted by abstinence length. The present results give grounds to suppose that chronic heroin taking induces neuronal oscillation frequency changes, that may contribute to the development of antisocial trends and some semantic processes disturbances in these patients. Supplementary neurophysiological deficit is characteristic for heroin addicts, who takes high doses of the drug, however, its relation to heroin abusing remains unclear. Pronounced desynchronization is observed in acute heroin withdrawal, and spectral power characteristics tend to normalize almost completely during several weeks of abstinence

Topics: RZ, RC0321, QP
Year: 2004
OAI identifier:
Provided by: e-Prints Soton

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  11. (1996). Electro-encephalography spectral analysis of heroin addicts compared with abstainers and normal controls.
  12. (1999). Hypoxic/ischaemic brain damage, especially pallidal lesions, in heroin addicts. Forensic Sci.
  13. (1995). Increase of extracellular dopamine in the medial prefrontal cortex during spontaneous and naloxone-precipitated opiate abstinence.
  14. (1998). Induced alpha band power changes in the human EEG and attention.
  15. (1955). Manual for the Wechsler Adult Intelligence Scale.
  16. (1996). Neurobiology of Drug Abuse. In:
  17. (1996). Neuropsychiatry of Alcohol and Drug Abuse.
  18. (2001). Neuropsychological deficit in chronic heroin abusers.
  19. (1995). On the relationship between EEG and ERP variability.
  20. (1996). Overdose among heroin users in Sydney, Australia: I. Prevalence and correlates of non-fatal overdose.
  21. (1997). Participation of noradrenergic pathways in the expression of opiate withdrawal: biochemical and pharmacological evidence.
  22. (1975). Physiological and psychological effects of methadone in men.
  23. (1990). Planning and spatial working memory following frontal lobe lesions in man.
  24. (2001). Predictors and prevention of nonfatal overdose among street-recruited injection heroin users in the San Francisco Bay Area,
  25. (2002). Premorbid psychological status in heroin abusers: Impact on treatment compliance. Zh Nevrol Psikhiatr Im S.S.
  26. (1997). Quantitative electroencephalographic differences associated with alcohol, cocaine, heroin and dual-substance dependence. Drug Alcohol Depend.
  27. (1998). Regional cerebral blood flow and comorbid diagnosis in abstinent opioid addicts. Psychiatry Res.
  28. (1982). Specific impairments of planning.
  29. (1990). Stroke from alcohol and drug abuse.
  30. (1997). The effects of haloperidol on visual search, eye movements and psychomotor performance.

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