Compatibility and stability of 8% amino acids solution in combination with electrolytes, vitamins and antibiotics

Abstract

For centuries, researchers have attempted to devise the ideal parenteral nutritional product readily amenable to physiological requirements. Hyperalimentation, intravenous alimentation, parenteral alimentation, parenteral feeding, and total parenteral nutrition are synonyms which refer to a method of complete intravenous nutrition reserved for patients demonstrating negative nitrogen balance. The nutrient solution appeared to accommodate levels of potassium phosphate, calcium gluconate, and magnesium sulfate well in excess of “usual” therapeutic concentrations. Similarly, commonly employed vitamin supplements and insulin were examined in combination with the hyperalimentation solution and failed to demonstrate signs of physical incompatibility. However, instrumental analysis, i.e., U.V. spectroscopy and thin-layer chromatography, suggested, in fact, there may have been chemical interaction of Solu B Forte and MVI once admixed with the amino acids/dextrose solution. Yet, results of thin-layer chromatography did not appear to substantiate chemical interaction between MVI and the amino acids solution. The investigator contends further study of multiple vitamin infusion stability be completed before definite conclusions are formulated regarding their compatibility in this nutritional infusate