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Vergleich zweier MRT-Kontrastmittel mit unterschiedlicher T1-Relaxivität zur Gefäßdarstellung bei Patienten mit abdominellen Aortenaneurysmen

By Henning Dömer

Abstract

The aim of this tripartite work is the comparison of different paramagnetic contrast agents in the examination of the infrarenal arterial vascular tree in magnetic resonance imaging (MRI) at 1.5 T in a group of patients with infrarenal aortic aneurysms. The two gadolinium-based contrast agents used are Gadopentat dimeglumine or Gd-DTPA (Magnevist®, Schering, Germany) and Gadobenate dimeglumine or Gd-BOPTA (MultiHance®, Bracco, Italy). They differ through their effect on the T1-relaxation of blood. Gadobenate dimeglumine shows a significantly higher relaxivity R in human plasma at 39°C and 20Mhz of R1 = 9.7mM-1s-1, in contrast to R1 = 4.9mM-1s-1 for Gadopentat dimeglumine. The findings of the examinations with the different contrast agents were compared with the current standard procedures in angiography, digital subtraction angiography (DSA) and computed tomography (CT). The findings have been diagnosed by 3 radiologists and have been compared regarding the quality of imaging and the validity of findings. In a total 54-patient group this work demonstrates significant advantages in terms of image quality when using the contrast agent of higher T1-relaxivity by inter-individual comparison. Among its use equivalent results in the quality of images compared to DSA for almost the entire infrarenal arterial vascular system are shown. The quality of images for magnetic resonance imaging using Gd-BOPTA is superior to those using Gd-DTPA in almost all examined vessels. The correspondence of findings for MRI and DSA as the reference method shows a higher validity by using Gd-BOPTA. Contrary to expectations no improvement in objectively measurable parameters of image quality using contrast agents in MRI compared to native MRI images can be pointed out in the present study. In planning the treatment of infrarenal abdominal aortic aneurysms imaging plays a crucial role. Currently computed tomography is the method of choice. In this work findings and measurements using contrast-enhanced MRI and CT were compared intraindividual. The quality of images is on a par for MRI and CT. All examined findings necessary for treatment can be shown correctly in MRI. In summary the present work shows an improved imaging quality and increased validity of findings in MRI compared with the current standard diagnostics DSA and CT by using contrast agents of higher T1 relaxivity

Topics: info:eu-repo/classification/ddc/610, Kontrastmittel, Aortenaneurysma, Magnetische Kernresonanz, NMR-Tomographie, Gadolinium, Spin-Gitter-Relaxation, Medizin, contrast agent, aortic aneurysm, NMR, gadolinium, spin-lattice relaxation time
Publisher: Publikationsserver der RWTH Aachen University
Year: 2009
OAI identifier: oai:publications.rwth-aachen.de:51414
Provided by: RWTH Publications
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