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Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package

By Paul Brennan

Abstract

SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain

Topics: Drug Discovery, Structural Genomics, Chemical Biology, malaria, drug discovery, genetics, neuropsychiatry, infectious disease, structure discovery, Target Enabling Package, protein, disease, neurological genetic disorders, chemical probe, orphan disease, chemical biology, structure, neuro, cancer, oncology, PHIP, metabolic diseases, drug target, structural genomics
Publisher: 'Blavatnik School of Government, University of Oxford'
Year: 2018
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