The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency.
In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.Peer reviewe
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell/virology, Cervical Intraepithelial Neoplasia/virology, Cross-Sectional Studies, Female, Human papillomavirus 18/isolation & purification, Humans, Middle Aged, Uterine Cervical Neoplasms/virology, Life sciences :: Genetics & genetic processes, Sciences du vivant :: Génétique & processus génétiques
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