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The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency.

By Saskia BULK, J. Berkhof, L. Rozendaal, N. C. Fransen Daalmeijer, M. Gok, F. A. de Schipper, F. J. van Kemenade, P. J. F. Snijders and C. J. L. M. Meijer


In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.Peer reviewe

Topics: Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell/virology, Cervical Intraepithelial Neoplasia/virology, Cross-Sectional Studies, Female, Human papillomavirus 18/isolation & purification, Humans, Middle Aged, Uterine Cervical Neoplasms/virology, Life sciences :: Genetics & genetic processes, Sciences du vivant :: Génétique & processus génétiques
Year: 2007
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