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Exploring the Effect of Novel Small Molecules on Oligodendrocyte Precursor Proliferation

By Sagune Sakya

Abstract

Gliomas, a type of brain tumor, can be difficult to treat and have a poor survival rate. One pathway that leads to glioma formation is excessive signaling by platelet derived growth factors (PDGF) through PDGF receptor α (PDGFRα). Through this research, I found that novel compounds that downregulate PDGFRα decrease proliferation of Oli-neu cells, an oligodendrocyte precursor cell model, and identified signaling pathways through which these compounds may exert their effect. Further investigation may identify targets for development of glioma treatments

Topics: PDGFR, oligodendrocyte precursor cells, glioma, glioma treatment, platelet derived growth factor receptor, platelet derived growth factor, oli-neu cells, Cellular and Molecular Physiology, Medicinal Chemistry and Pharmaceutics, Molecular and Cellular Neuroscience, Nervous System Diseases
Publisher: OpenCommons@UConn
Year: 2016
OAI identifier: oai:opencommons.uconn.edu:usp_projects-1025

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