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Flash Chemistry on Multigram-Scale: Continuous Flow Synthesis of Boronic Acids within a Second

By Andreas Hafner, Mark Meisenbach and Joerg Mathias Sedelmeier


The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on multigram-scale is described. The developed metalation platform allows for the performance of organolithium chemistry on mulitgram scale mimicking the concept of flash chemistry. This setup embodies a valuable complement to existing methodologies as it combines the benefits of Flash Chemistry (chemical synthesis on a timescale of <1 s) with remarkable throughput while mitigating the risk of blockages

Year: 2016
DOI identifier: 10.1021/acs.orglett.6b01681
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