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Tivantinib (ARQ 197) affects the apoptotic and proliferative machinery downstream of c-MET: role of Mcl-1, Bcl-xl and Cyclin B1

By Shuai Lu, Helga-Paula Török, Eike Gallmeier, Frank T Kolligs, Antonia Rizzani, Sabrina Arena, Burkhard Göke, Alexander L Gerbes and Enrico N De Toni
Topics: HCC; apoptosis; c-MET; targeted therapies; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Colorectal Neoplasms; Cyclin B1; Hep G2 Cells; Humans; Liver Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrrolidinones; Quinolines; bcl-X Protein
Publisher: 'Impact Journals, LLC'
Year: 2015
DOI identifier: 10.18632/oncotarget.4240
OAI identifier: oai:iris.unito.it:2318/1614897

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