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Risk factors for bacterial pneumonia after cytotoxic chemotherapy in advanced lung cancer patients

By Jeong-Ok Lee, Dae-Young Kim, Joo Han Lim, Myung-Deock Seo, Hyeon Gyu Yi, Yu Jung Kim, Se-Hoon Lee, Dong-Wan Kim, Seok-Chul Yang, Young Whan Kim and Dae Seog Heo


The purpose of this study was to demonstrate the prevalence of and risk factors for pneumonia after cytotoxic chemotherapy in advanced lung cancer patients. We retrospectively reviewed 193 out of 215 advanced lung cancer patients who were consecutively treated with cytotoxic chemotherapy at Seoul National University Hospital in 2005. The mean age was 61 years (range, 31-85 years). A total of 41 patients (21%) had Eastern cooperative oncology group (ECOG) performance status 2-3. Among 135 patients with pulmonary function test (PFT), 34% (n=46) of patients demonstrated an obstructive pattern of lung function. Pneumonia occurred in a total of 10 patients (5%). Occurrence rate was significantly higher in older patients (>70 years) than in younger ones (13% vs. 4%, p=0.05), higher in patients with ECOG 2-3 compared with those with ECOG 0-1 (15% vs. 3%, p<0.01), and higher in patients with an obstructive pattern of lung function compared with those without (11% vs. 1%, p=0.02). Pneumonia occurrence rate in patients with all three risk factors was 25%. Six out of 10 pneumonia patients required hospitalization, and one patient died from respiratory failure. We identified this high-risk group as a candidate for antibacterial prophylaxis after cytotoxic chemotherapy in advanced lung cancer patients.This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea(0412-CR01-0704-0001)

Topics: Adult, Aged, Aged, 80 and over, Antineoplastic Agents/*adverse effects, Carcinoma, Non-Small-Cell Lung/*drug therapy, Humans, Incidence, Lung Neoplasms/*drug therapy, Male, Middle Aged, Neoplasm Staging, Pneumonia, Bacterial/epidemiology/*etiology, Prognosis, Retrospective Studies, Risk Factors, Small Cell Lung Carcinoma/*drug therapy
Publisher: Elsevier
Year: 2008
DOI identifier: 10.1016/j.lungcan.2008.03.015
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