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The silver-releasing foam dressing, contreet foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial

By Bo Jorgensen, Patricia Price, Klaus E. Andersen, Finn Gottrup, Niels Bech-Thomsen, Elizabeth Scanlon, Robert Kirsner, Henriette Rheinen, Jyette Roed-Petersen, Marco Romanelli, Gregor Jemec, David J. Leaper, Martino Ha Neumann, Joep Veraart, Stefan Coerper, Rikke H. Agersley, Susanne H. Bendz, Jan R. Larsen and R. Gary Sibbald

Abstract

The study compared the effect of a sustained silver-release foam dressing (Contreet Foam) with a foam dressing (Allevyn Hydrocellular) without added silver in critically colonised venous leg ulcers with delayed healing. The study was a multicentre, open, randomised, controlled study lasting for 4 weeks. Ulcer area and healing were assessed weekly. Odour, maceration, absorption capacity and leakage were evaluated at dressing changes. All adverse events were recorded. One hundred and twenty-nine patients were included (Contreet Foam: 65, Allevyn Hydrocellular: 64). The two groups were comparable in all respects. After 4 weeks, there was a significantly greater reduction in ulcer area in the Contreet Foam group (45%) than in the Allevyn Hydrocellular group (25%). After 1 and 4 weeks, odour was present in significantly less of the ulcers in the Contreet Foam group (17% and 19%, respectively) compared with the Allevyn Hydrocellular group (47% and 39%, respectively) and at the final visit there were significantly fewer leakages in the Contreet Foam group (19%) compared with the Allevyn Hydrocellular group (49%). Also, less maceration was observed after 1 and 4 weeks in the Contreet Foam group (34% and 37%, respectively) compared with the Allevyn Hydrocellular group (55% and 48%, respectively). The occurrence and cause of adverse events were equally distributed between the study groups. The present study provides evidence of the superior performance of the silver-releasing dressing, Contreet Foam, compared with a traditional moist foam wound healing dressing in the treatment of critically colonised, chronic venous leg ulcers. The results of this randomised, controlled study suggest an important role of sustained silver-releasing dressings in the treatment of critically colonised chronic wound

Topics: RT
Year: 2005
OAI identifier: oai:eprints.soton.ac.uk:40819
Provided by: e-Prints Soton
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