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Effects on cognition of stereotactic lesional surgery for the treatment of tremor in multiple sclerosis

By Marjan Jahanshahi, Socorro Pieter, Sundus H. Alusi, Catherine R. G. Jones, Scott Glickman, John Stein, Tipu Aziz and Peter G. Bain

Abstract

Objective: To assess the effect of stereotactic lesional surgery for treatment of tremor in multiple sclerosis on cognition. Methods: Eleven patients (3 males, 8 females) with multiple sclerosis participated in the study. Six subjects comprised the surgical group and five the matched control group. All patients were assessed at baseline and three months using a neuropsychological test battery that included measures of intellectual ability, memory, language, perception and executive function. Results: There were no significant differences between the surgical and control groups and no change from pre to post testing except for a decline in scores on the Mini-Mental State Examination (MMSE), WAIS-R Digit Span and Verbal Fluency in the surgical group. Conclusions: The results indicate that stereotactic lesional surgery does not result in major cognitive impairment in multiple sclerosis. However, the decline in MMSE scores, digit span and verbal fluency require further investigation in a larger sample

Topics: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: IOS Press
Year: 2008
DOI identifier: 10.3233/BEN-2008-0207
OAI identifier: oai:http://orca.cf.ac.uk:48295
Provided by: ORCA
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