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Poly(ß,L-malic acid)/Doxorubicin ionic complex: A pH-dependent delivery system

By Alberto Lanz Landazuri, Domingo Antxon Martínez de Ilarduya Sáez de Asteasu, Montserrat García Álvarez and Sebastián Muñoz Guerra


Poly(beta,L-malic acid) (PMLA) was made to interact with the cationic anticancer drug Doxorubicin (DOX) in aqueous solution to form ionic complexes with different compositions and an efficiency near to 100%. The PMLA/DOX complexes were characterized by spectroscopy, thermal analysis, and scanning electron microscopy. According to their composition, the PMLA/DOX complexes spontaneously self-assembled into spherical micro or nanoparticles with negative surface charge. Hydrolytic degradation of PMLA/ DOX complexes took place by cleavage of the main chain ester bond and simultaneous release of the drug. In vitro drug release studies revealed that DOX delivery from the complexes was favored by acidic pH and high ionic strength.Peer Reviewe

Topics: Àrees temàtiques de la UPC::Enginyeria química, Polymers, Poly(malic acid), Ionic complexes, Doxorubicin complex, pH-dependent, Drug-delivery particle, Polímers
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