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Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome

By Andrew J Finch, Christine Hilcenko, Nicolas Basse, Lesley F Drynan, Beatriz Goyenechea, Tobias F Menne, Africa González Fernández, Paul Simpson, Clive S D'Santos, Mark J Arends, Jean Donadieu, Christine Bellanné-Chantelot, Michael Costanzo, Charles Boone, Andrew N McKenzie, Stefan M V Freund and Alan J Warren
Topics: Animals, Lipomatosis, Peptide Initiation Factors, Eukaryotic Initiation Factors, Models, Molecular, Humans, Disease Models, Animal, Ribosomes, Mice, Protein Binding, Hydrolysis, Ribosome Subunits, Large, Eukaryotic, Guanosine Triphosphate, Phosphorylation, Cells, Cultured, Mice, Inbred C57BL, Liver, Proteins, Protein Structure, Tertiary, Bone Marrow Diseases, Mutation, Exocrine Pancreatic Insufficiency, Catalysis, /dk/atira/pure/subjectarea/asjc/2700, Medicine(all)
Publisher: 'Cold Spring Harbor Laboratory'
Year: 2011
DOI identifier: 10.1101/gad.623011
OAI identifier:

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