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Assembly of Double-Hydrophilic Block Copolymers Triggered by Gadolinium Ions: New Colloidal MRI Contrast Agents

By Camille Frangville, Yichen Li, Claire Billotey, Daniel Talham, Jacqueline Taleb, Patrick Roux, Daniel Marty and Christophe Mingotaud

Abstract

International audienceMixing double-hydrophilic block copolymers containing a poly(acrylic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are exceptionally stable, even after dilution and over a large range of pH and ionic strength. High magnetic relaxivities were measured in vitro for these biocompatible colloids, and in vivo magnetic resonance imaging on rats demonstrates the potential utility of such polymeric assemblies

Topics: nanoparticle, gadolinium, Magnetic Resonance Imaging, MRI, micelle, block copolymer, Polymer, [CHIM.POLY]Chemical Sciences/Polymers, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], [CHIM]Chemical Sciences
Publisher: 'American Chemical Society (ACS)'
Year: 2016
DOI identifier: 10.1021/acs.nanolett.6b00664
OAI identifier: oai:HAL:hal-02195760v1
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