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Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease

By Jadranka Miletić Vukajlović, Dunja Drakulić, Snežana Pejić, Tihomir V. Ilić, Aleksandra Stefanović, Marijana Petković and Jürgen Schiller

Abstract

Rationale: Changes in lipid composition might be associated with the onset and progression of various neurodegenerative diseases. Herein, we investigated the changes in the plasma phosphatidylcholine (PC)/lysophosphatidylcholine (LPC) ratios in patients with Parkinson's disease (PD) in comparison with healthy subjects and their correlation with clinico-pathological features. Methods: The study included 10 controls and 25 patients with PD. All patients were assigned to groups based on clinico-pathological characteristics (gender, age at examination, duration of disease and Hoehn and Yahr (H&Y) stage). The analysis of the PC/LPC intensity ratios in plasma lipid extracts was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Results: PD patients exhibited an increased PC/LPC intensity ratio in comparison with the control group of healthy subjects. Furthermore, the investigated ratio was shown to be correlated with clinico-pathological parameters, in particular with H&Y stage and disease duration. The PC/LPC intensity ratio in plasma samples of PD patients was found to be elevated in all examined H&Y stages and throughout the disease duration. Conclusions: To our knowledge, this is the first study examining the PC/LPC ratios in plasma of patients with PD and illustrating their correlation with clinico-pathological features. Although the presented results may be considered as preliminary due to the limited number of participants, the observed alterations of PC/LPC ratios in plasma might be a first step in the characterization of plasma lipid changes in PD patients and an indicator of lipid reconfiguration

Topics: MALDI-TOF MS, PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE ACTIVITY, PHOSPHOLIPASE A(2) ACTIVITY, LIPID-PEROXIDATION, MASS-SPECTROMETRY, O-ACYLTRANSFERASE, SUBSTANTIA-NIGRA, OXIDATIVE STRESS, FATTY-ACID, LYSOPHOSPHATIDYLCHOLINE
Publisher: 'Wiley'
Year: 2020
DOI identifier: 10.1002/rcm.8595
OAI identifier: oai:farfar.pharmacy.bg.ac.rs:123456789/3522
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