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Human body and chromium [Insan vücudu ve krom]

By Karagün B.Ş., Özer G., Şahbaz Ö., Mazman M. and Karagün G.M.


Chromium is an essential trace element that plays a role in carbohydrate metabolism. Chromium is required for optimal insulin activity and maintenance of normal glucose tolarence. Chromium deficiency is associated with elevated blood glucose and decreased high density lipoprotein (HDL) and insulin levels. If chromium intakes adequately from diet it protects people from two important diseases (cardiovascular diseases and diabetes mellitus) that develop due to chromium deficiency. Essential trace elements play a key role in enzyme systems also they have lots of roles that include are in organisation of winter structures such as mitochondrium and ribozome and neural transmission activity of enzymes and membran transport. They have function about protection and construction of protein and nucleic acids and stabilization of ribozomal structures. Inadequacy of these elements in serum and tissues cause decreasing an activation of metabolic events that directed by enzymes. The absorbtion of chromium was greatest in the jejenum followed by the duedenum and ileum by diffusion. Chromium primarily binds to the beta globulin following absorbtion only small amounts of chromium were bound to albumin gama globulin alfa-1 and alfa-2 globulin. It mainly excreted through the kidneys but small amounts of chromium are lost in hair sweat and bile and it can not be reabsorbed by the kidney. Adequate daily dietary intake for chromium in adults aprroximately 50-100 mcg/dl analyzing of chromium is difficult due to its low concentrations in biological materials. Such low consecrations restrict the techniques for chromium analysis to atomic absorption spectrometry graphite furnace mass spectrometry and neutron activation analyse. Trivalent chromium (+3) has a low order of toxicity becomes only at extremely high amounts, however hemalent chromium is extremely toxic. Chromium is vitally essential trace element for maintenance of normal glocose tolerance

Year: 2006
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