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Clinical and histopathological findings of 'psoriatic neurodermatitis' and of typical lichen simplex chronicus

By Gunasti S., Marakli S.S., Tuncer I., Ozpoyraz N. and Aksungur V.L.


PubMedID: 17567313Background: We have seen several patients with itchy lichenified plaques located bilaterally on the elbows and/or knees and have named this condition 'psoriatic neurodermatitis' (PN). Objective: The purpose of this study was to compare clinical and histopathological characteristics of these patients to those of patients with typical lichen simplex chronicus (LSC). Methods: Nineteen patientswith PN and 34 patients with typical LSC were included. Besides clinical dermatological evaluation, the prick test was carried out on 49 patients; the Phadiatop test on 40 patients; the patch test with European standard series on 47 patients; histopathological evaluation on 39 patients; and clinical psychiatric examination on 38 patients. Results: Almost exclusively, PN was seen in females and was located on the extremities. It caused more plaques than typical LSC did. In PN, the plaques were smaller, sharper, more keratotic and less excoriated, and had fewer lichenoid papules around them. Itching was usually more severe in the evening, while resting and in a hot environment in typical LSC, but not in PN. In plaques of PN, microabscesses in the horny layer, hypogranulosis, regular acanthosis and thinning of the suprapapillary plates were more frequent, and hyperpigmentation in the basal layer was less. In patients with PN, depressive disorder was found more frequently; and generalized anxiety disorder or psychosomatic characteristics, less. There were no significant differences in the results of prick, Phadiatop and patch tests between patients with PN and those with typical LSC. Conclusion: In our opinion, it is most likely that the so-called PN is itchy psoriasis superimposed by LSC. © 2007 The Authors Journal compilation © 2007 European Academy of Dermatology and Venereology

Topics: Epidermal hyperplasia, Excoriation, Itching, Lichen simplex chronicus, Psoriasis
Year: 2007
DOI identifier: 10.1111/j.1468-3083.2006.02055.x
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