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Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells

By S. Willaime-Morawek, R.M. Seaberg, C. Batista, E. Labbé, L. Attisano, J.A. Gorski, K.R. Jones, C.M. Morshead and D. van der Kooy


Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells from midgestation into adulthood. Lineage tracing in combination with direct cell labeling and time-lapse video microscopy demonstrated that Emx1-lineage embryonic cortical stem cells migrate ventrally into the striatal germinal zone (GZ) perinatally and intermingle with striatal stem cells. Upon integration into the striatal GZ, cortical stem cells down-regulate Emx1 and up-regulate Dlx2, which is a homeobox gene characteristic of the developing striatum and striatal neural stem cells. This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain

Topics: QH301, QH426, RC0321
Year: 2006
OAI identifier:
Provided by: e-Prints Soton

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