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Characterization of cellular chemical dynamics using combined microfluidic and Raman techniques

By Xunli Zhang, Huabing Yin, Jon M. Cooper and Stephen J. Haswell


The integration of a range of technologies including microfluidics, surface-enhanced Raman scattering and confocal microspectroscopy has been successfully used to characterize in situ single living CHO (Chinese hamster ovary) cells with a high degree of spatial (in three dimensions) and temporal (1 s per spectrum) resolution. Following the introduction of a continuous flow of ionomycin, the real time spectral response from the cell was monitored during the agonist-evoked Ca2+ flux process. The methodology described has the potential to be used for the study of the cellular dynamics of a range of signalling processes

Topics: QD, QH301
Year: 2008
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Provided by: e-Prints Soton
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