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Genetic selection of cyclic peptide dam methyltransferase inhibitors

By Todd A. Naumann, Ali Tavassoli and Stephen J. Benkovic

Abstract

We report the development of a transposition based genetic selection methodology used to uncover three cyclic peptide inhibitors of the E. coli methyltransferase. The activity of the selected cyclic peptides was confirmed in vivo and in vitro. The IC50 of the most active cyclic peptide (SGWYVRNM, shown in the figure) was comparable to that of the known methyltransferase inhibitor, sinefungin

Topics: QH301
Year: 2008
OAI identifier: oai:eprints.soton.ac.uk:54487
Provided by: e-Prints Soton
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