Due to the existing depression, industrial enterprises in most of the world require to be reconfigured and/or reorganized especially the manufacturing firms (companies). As a consequence of the global economic crisis (GEC), great political and economical maybe changed and some companies will go out from business and others will be merged with other firms. Also, a big effecting will be represented in unemployment. The industrial enterprises will start to deal intensively for better utilization of resources (e.g., equipments, machines, etc.) and human resources. There are a lot of issues needed to be addressed to cope with this recession. The most important issue is then the opportunity to learn new skills and techniques. The other issues which this paper illustrated representing in complexity level of industrial enterprises, designing hybrid or innovative manufacturing systems, applied manufacturing strategies and philosophies, product development, management for change, and good accounting system. In this paper, a conceptual framework as a roadmap for discussing these issues of reconfiguring industrial enterprises will be explained and discussed. The analysis shows that reconfiguring industrial enterprises is not easy task and a multi-dimensional problem
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