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Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution

By M&amp, Nematian-Samani M and Eichel A

Abstract

R Mösges, M Nematian-Samani, A EichelInstitute of Medical Statistics, Informatics and Epidemiology, Faculty of Medicine, University of Cologne, GermanyBackground/objective: An inflammation of the cutis and subcutis of the external auditory canal is a primary symptom in cases of acute otitis externa. It is usually treated locally, since this type of therapy ensures a high concentration of the drug and interacts at the site of inflammation with no systemic effects. This systematic review compares the efficacy of treatment using a ciprofloxacin 0.2% solution with other therapeutic options.Methods: After compiling a catalog of search terms, medical databases were searched systematically for randomized, controlled studies. This search initially yielded a total of 38 studies which were then evaluated by three independent reviewers. The number of studies was subsequently reduced to 14: six studies using a ciprofloxacin 0.2% solution, and eight studies using both 0.2% and 0.3% solutions.Results: The studies included in the review demonstrate the statistical equivalence between the ciprofloxacin solution (0.2%) and the reference products PNH (a combination of polymyxin B, neomycin sulfate and hydrocortisone), auriculum powder, and a ciprofloxacin foam with respect to the cure rate. The research groups consistently observed high in vitro activity of ciprofloxacin against Pseudomonas aeruginosa.Conclusion: This systematic review confirms the hypothesis of ciprofloxacin's noninferiority in the treatment of otitis externa, in terms of the cure rate and microbiological eradication.Keywords: otitis externa, ciprofloxacin, antibiotic, ear solution, efficac

Topics: LCC:Pharmacy and materia medica, LCC:RS1-441, LCC:Medicine, LCC:R, DOAJ:Pharmacy and materia medica, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Dove Press
Year: 2011
OAI identifier: oai:doaj.org/article:fa7995e89656448bbcd9f31730e87fb5
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