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Epidemiological analysis of bacterial strains involved in hospital infection in a University Hospital from Brazil Análise epidemiológica de cepas bacterianas envolvidas em infecção hospitalar em um Hospital Universitário no Brasil

By Bianca Aguiar de MORAES, Cristiane Andrade Nery CRAVO, Marcio Martins LOUREIRO, Claude André SOLARI and Marise Dutra ASENSI

Abstract

Hospital infections cause an increase in morbidity and mortality of hospitalized patients with significant rise in hospital costs. The aim of this work was an epidemiological analysis of hospital infection cases occurred in a public University Hospital in Rio de Janeiro. Hence, 238 strains were isolated from 14 different clinical materials of 166 patients hospitalized in the period between August 1995 and July 1997. The average age of the patients was 33.4 years, 72.9% used antimicrobials before having a positive culture. The most common risk conditions were surgery (19.3%), positive HIV or AIDS (18.1%) and lung disease (16.9%). 24 different bacterial species were identified, S. aureus (21%) and P. aeruginosa (18.5%) were predominant. Among 50 S. aureus isolated strains 36% were classified as MRSA (Methicillin Resistant S. aureus). The Gram negative bacteria presented high resistance to aminoglycosides and cephalosporins. A diarrhea outbreak, detected in high-risk neonatology ward, was caused by Salmonella serovar Infantis strain, with high antimicrobial resistance and a plasmid of high molecular weight (98Mda) containing virulence genes and positive for R factor.<br>As infecções hospitalares representam um aumento na morbidade e mortalidade de pacientes internados, com significativo aumento no custo de internação hospitalar. Teve-se como objetivo fazer uma análise epidemiológica de casos de infecção hospitalar ocorridos num Hospital Universitário na cidade do Rio de Janeiro. Assim, foram analisadas 238 cepas isoladas a partir de 14 espécimens clínicos diferentes oriundos de 166 pacientes internados no período de 08 de 1995 a 07 de 1997. A idade média dos pacientes foi de 33,4 anos, 72,9% faziam uso de antimicrobiano antes de apresentar a cultura positiva, as patologias de risco mais comuns foram: Cirurgia (19,3%), HIV ou AIDS positivo (18,1%) e Patologia Pulmonar (16,9%). Foram identificadas 24 espécies bacterianas distintas, com predominância de S. aureus (21%) e P. aeruginosa (18,5%). Foram detectados 36% de MRSA (Methicilin Resistant S. aureus). Os Gram negativos apresentaram altos níveis de resistência para aminoglicosídeos e cefalosporinas. Foi detectado um surto de diarréia em berçário patológico, provocado pela Salmonella sorovar Infantis, com altos níveis de resistência para antimicrobianos e um plasmídio de alto peso molecular (98Mda), codificador do fator R

Topics: Hospital infection, Antimicrobial resistance, Salmonella outbreak, LCC:Medicine (General), LCC:R5-920, LCC:Medicine, LCC:R, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Instituto de Medicina Tropical
Year: 2000
DOI identifier: 10.1590/S0036-46652000000400005
OAI identifier: oai:doaj.org/article:6d7b38376d7546448efdb7f182a14123
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