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Total IgE detection in paired cerebrospinal fluid and serum samples from patients with neurocysticercosis Detecção de IgE total em amostras pareadas de líquido cefalorraquiano e soro de pacientes com neurocisticercose

By Ednéia Casagranda BUENO, Adelaide José VAZ, Luís dos Ramos MACHADO and José Antônio LIVRAMENTO

Abstract

Neurocysticercosis (NC), the presence of Taenia solium metacestodes in tissues, is the most frequent and severe parasitic infection of the central nervous system. We investigated the presence of total IgE by an automated chemiluminescence assay in 53 paired cerebrospinal fluid (CSF) and serum samples from patients with NC (P) and in 40 CSF samples from individuals with other neurological disorders as the control group (C). Total IgE concentration ranged from 1.2 to 6.6 IU/ml (mean = 1.4 IU/ml, standard deviation-sd = 1.1 IU/ml) in 28.3% of CSF samples from the P group, a value significantly higher than for the C group (£1.0 IU/ml). The serum samples from the P group showed concentrations ranging from 1.0 to 2330.0 IU/ml (mean = 224.1 IU/ml, sd = 452.1 IU/ml), which were higher than the normal value cited by the manufacturer (<100.0 IU/ml) in 32.1% of the samples. A significant difference was observed in CSF samples from the P and C groups (p = 0.005) and in serum samples from the P group compared to the normal value (p = 0.005), with sera showing more frequent abnormal results.<br>Neurocisticercose (NC), causada pela presença da forma larvária de Taenia solium em tecidos, é a mais frequente e grave infecção parasitária que acomete o sistema nervoso central. Nós investigamos a presença de IgE total por quimiluminescência em 53 amostras pareadas de líquido cefalorraquiano (LCR) e soro de pacientes com NC (P) e 40 amostras de LCR de indivíduos portadores de outras desordens neurológicas como grupo controle (C). A detecção de IgE total mostrou 28,3% das amostras de LCR do grupo P com concentrações entre 1,2 UI/ml e 6,6 UI/ml (média = 1,4 UI/ml, desvio padrão-sd = 1,1 UI/ml), maiores que o grupo C (£1,0 UI/ml). As amostras de soro do grupo P mostraram concentrações entre 1,0 UI/ml e 2330,0 UI/ml (média = 224.1 UI/ml, sd = 452,1 UI/ml), e 32,1% das amostras apresentaram valores maiores que o valor normal citado pelo fabricante (<100,0 UI/ml). Diferença significativa foi encontrada entre as amostras de LCR dos grupos P e C (p = 0,005) e entre as amostras de soro do grupo P e valor de referência (p = 0,005), sendo os resultados dos soros mais frequentemente alterados

Topics: Cysticercosis, IgE, Serum, CSF, LCC:Medicine (General), LCC:R5-920, LCC:Medicine, LCC:R, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Instituto de Medicina Tropical
Year: 2000
DOI identifier: 10.1590/S0036-46652000000200002
OAI identifier: oai:doaj.org/article:d6e73323c54c4e6883ef0bf6f563a5ea
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