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Synthesis of agonists and atagonists for central glutamate receptors by a novel 'ring switching' strategy

By Andrew Bowler, Andrew Dinsmore, Paul M Doyle and Douglas W Young


A novel and versatile ring switching strategy has been developed for the synthesis of compounds with structural features consistent with activity at glutamate receptors. A variety of homochiral L-alanine derivatives substituted at the β-carbon atom with planar five and six-membered heteroaromatic rings have been prepared in a one- or two-pot reaction using this strategy and some of the products have been shown to have biological activity at central glutamate receptors

Publisher: RSC Publishing
Year: 1997
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