Article thumbnail
Location of Repository

Memory, cAMP, and PACAP-a phylogenetically conserved function? Studies in Lymnea stagnalis

By Z Pirger, Z Laszlo, L Hiripi, D Reglodi, A Lubics, L Mark and G Kemenes

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved polypeptide, which, along with its receptors (PAC1-R, VPAC1, and VPAC2), is expressed in both vertebrate and invertebrate nervous systems. In the first part of the present study, we showed the presence of PACAP in Lymnea stagnalis by mass spectrometry and investigated whether PACAP elevates cAMP in cerebral ganglia. VIP, PACAP, and maxadilan increased cAMP levels by ~47, 79, and 82% of control levels, respectively, and this effect could be blocked by the co-application of the antagonist PACAP6-38 and maxadilan antagonist

Year: 2010
OAI identifier: oai:sro.sussex.ac.uk:19088
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://dx.doi.org/10.1007/s120... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.