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Calcium signaling in the cochlea – Molecular mechanisms and physiopathological implications

By Ceriani Federico and Mammano Fabio


<p>Abstract</p> <p>Calcium ions (Ca<sup>2+</sup>) regulate numerous and diverse aspects of cochlear and vestibular physiology. This review focuses on the Ca<sup>2+</sup> control of mechanotransduction and synaptic transmission in sensory hair cells, as well as on Ca<sup>2+</sup> signalling in non-sensory cells of the developing cochlea.</p

Topics: Hearing, Inner ear, Transducer adaptation, Ca<sup>2+</sup> channels, Cadherin 23, Protocadherin 15, Plasma-membrane Ca<sup>2+</sup>-ATPase, Prestin, Intracellular stores, Calcium release, Mitochondria, Ribbon synapse, Adenosine-5'-triphosphate, Inositol 1,4,5-trisphosphate, Connexin 26, Connexin 30, Deafness, Mouse models, Medicine, R, Cytology, QH573-671
Publisher: BMC
Year: 2012
DOI identifier: 10.1186/1478-811X-10-20
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