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A Synthesis of (+)- Prelog-Djerassi Lactonic Acid

By Stephen K Wrigley, Martin A Hayes, Robert Thomas, Ewan J T Chrystal, Neville Nicholson, Steven Hiscock, Peter Hitchcock and Philip Parsons


A new approach to the synthesis of Prelog-Djerassi Lactonic acid (1) is reported. A key step in this synthesis involves an Ireland-Claisen rearrangement/silicon-mediated fragmentation sequence to provide the carbon framework in (

Publisher: Tetrahedron
Year: 1998
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