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Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination

By Mathias Streitz, Stephan Fuhrmann, Fiona Powell, Ali Quassem, Laurel Nomura, Holden Maecker, Peter Martus, Hans-Dieter Volk and Florian Kern

Abstract

Functional characteristics of tuberculosis (TB)-specific CD4 T cells were studied in clinically active pulmonary TB (n = 21) and high TB exposure including LTBI (n = 17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon gamma [IFN-gamma], tumor necrosis factor alpha [TNF-alpha], and interleukin 2 [IL-2\ production). Interestingly, CD154 up-regulation accounted for similar to 80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-gamma accounted for only similar to 50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-gamma production alone

Topics: QR, QR180, RC0109
Publisher: Oxford University Press
Year: 2011
OAI identifier: oai:sro.sussex.ac.uk:7241
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