Article thumbnail
Location of Repository

Deletion variant of alpha 2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance

By Ayana A. Gibbs, Kris H. Naudts, Ruben T. Azevedo and Anthony S. David


The COMT val(158) variant has been associated with impaired cognitive function compared to the Met(158) variant yet gene gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha 2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to Met(158) carriers

Topics: RC0321, RC0346, RC0435, RM, RS
Publisher: Elsevier
Year: 2010
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.