Article thumbnail

The role of asenapine in the treatment of manic or mixed states associated with bipolar I disorder

By Pompili M, Venturini P, Innamorati M, Serafini G, Telesforo L, Lester D, Tatarelli R and Girardi P

Abstract

Maurizio Pompili1,2, Paola Venturini1, Marco Innamorati1, Gianluca Serafini1, Ludovica Telesforo1, David Lester3, Roberto Tatarelli1, Paolo Girardi11Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy; 2McLean Hospital, Harvard Medical School, Boston, MA, USA; 3The Richard Stockton College of New Jersey, Pomona, NJ, USABackground: Bipolar disorders (BD) are of particular public health significance as they are prevalent, severe and disabling, and often associated with elevated risks of premature mortality. The aim of this concise overview is to investigate the role of asenapine in the treatment of manic and mixed states associated with BD type 1 disorder.Method: MedLine, Excerpta Medica and PsycINFO searches were performed to identify papers in English published over the past 7 years. Search terms were "asenapine", "manic" OR "mixed states", "bipolar I disorder". Subjects included in this study suffered from BD type 1 disorder.Results: To date, only four studies of asenapine for the treatment of manic or mixed episodes associated with BD type 1 have been published.Conclusion: Research indicates that asenapine is generally well-tolerated, and that asenapine is efficacious and not inferior to olanzapine in the treatment of mixed or manic episodes associated with BD type 1 in the short-term and long-term.Keywords: asenapine, bipolar disorder, side effect

Topics: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Publisher: Dove Medical Press
Year: 2011
DOI identifier: 10.2147/ndt.s17259
OAI identifier: oai:doaj.org/article:1e7894ae2a7c438c9f7cc8c8b22ab13d
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1178-2021 (external link)
  • https://doaj.org/toc/1178-2021 (external link)
  • https://doaj.org/toc/1176-6328 (external link)
  • https://doaj.org/toc/1176-6328 (external link)
  • http://www.dovepress.com/the-r... (external link)
  • http://www.dovepress.com/the-r... (external link)
  • https://doaj.org/article/1e789... (external link)
  • https://doaj.org/article/1e789... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.