Correlation between transcutaneous oxygen partial pressure and nerve conduction determination in type 2 diabetic patients


Objectives  To investigate the correlation between transcutaneous oxygen partial pressure (TcPO2) and nerve conduction determination (NC) in type 2 diabetic patients. Methods  From January to July in 2012, 381 age-matched type 2 diabetic patients were enrolled in the Xi'nan Hospital of Third Military Medical University. These patients were divided into 4 groups depending on the results of NCS and symptoms of diabetic peripheral neuropathy (DPN), among which there were 129 with abnormal NCS but no DPN symptoms as group 1, 50 with DPN symptoms and normal NCS as group 2, 122 with both abnormal NCS and DPN symptoms as group 3 and 80 without abnormal NCS nor any DPN symptoms as group 4. Groups 1 and 3 served as DPN group, while groups 2 and 4 were respectively named as possible DPN group and non-DPN group. The differences of 33 indexes of TcPO2 in erect and recumbent positions, correlation between TcPO2 values and differences in erect and recumbent positions between groups, and the correlation between TcPO2 values and various NCS parameters were analyzed. Results  The values of TcPO2 in erect position and recumbent position in DPN and possible DPN group were lower, while the difference between them was higher than that (erect-recumbent position difference) in non-DPN group (P<0.05). The value of erect position TcPO2 was correlated with all the 26 parameters of NCS including the velocity of median nerve conduction, distal latency, amplitude of compound muscle action potential (P<0.05); the value of recumbent position TcPO2 was also correlated with almost all parameters except the shortest latency of F wave; the erect-recumbent position difference was correlated with 11 out of the above 26 parameters (P<0.05). Conclusion  There is a good correlation between TcPO2 and NCS, which suggests that TcPO2 can serve as a potential and effective method for detecting DPN at early stage

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