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Synthesis and antitubercular activity of 4-oxo-thiazolidine derivatives of 2-amino-5-nitrothiazole

By R. Sharma, P. Samadhiya and S.K. Srivastava

Abstract

New series of <i>N</i>-[3-(2-amino-5-nitrothiazolyl)-propyl]-2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine-carboxamide, <b>5(a-j)</b> have been synthesized from 2-amino-5-nitrothiazole as a starting material. The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and FAB-Mass. All the final synthesized compounds <b>5(a-j)</b> were screened for their antibacterial and antifungal activities against some selected bacteria and fungi with their MIC values and antitubercular activity screened against <i>M. tuberculosis</i>

Topics: Synthesis, 2-Amino-5-nitrothiazole, Thiazolidinone, Antimicrobial, Antitubercular, Chemistry, QD1-999
Publisher: Chemical Society of Ethiopia
Year: 2013
DOI identifier: 10.4314/bcse.v27i2.10
OAI identifier: oai:doaj.org/article:6e3d0f5601f848b7b8e1acb155e582aa
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