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Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1? in cancer: role of free radical formation

By Marisol Quintero, Peter A. Brennan, Gareth J. Thomas and Salvador Moncada


Widespread expression of the ?-subunit of hypoxia-induciblefactor (HIF-1?) was observed in samples of human oral squamous cell carcinoma. In all the cases, this was accompanied by a widespread distribution of nitric oxide (NO) synthases (NOS). Furthermore, in three human cell lines derived from human oral squamous cell carcinoma, the accumulation of HIF-1? was prevented either by inhibition of NOS activity with the nonspecific NOS inhibitor NG- monomethyl-L-arginine or by the antioxidants N-acetyl-Lcysteine and ascorbic acid. We suggest that, in certain forms of cancer, NO might be responsible for the accumulation of HIF-1? by a mechanism dependent on free radicals

Topics: RB, RC0254
Year: 2006
OAI identifier: oai:eprints.soton.ac.uk:66688
Provided by: e-Prints Soton
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