Article thumbnail
Location of Repository

Enalapril alters the formation of the collagen matrix in spontaneously hypertensive rats

By Bomfim Alfredo de Souza and Mandarim-de-Lacerda Carlos Alberto

Abstract

OBJECTIVE: To assess the effect of the inhibition of the angiotensin-converting enzyme on the collagen matrix (CM) of the heart of newborn spontaneously hypertensive rats (SHR) during embryonic development. METHODS: The study comprised the 2 following groups of SHR (n=5 each): treated group - rats conceived from SHR females treated with enalapril maleate (15 mg. kg-1.day-1) during gestation; and nontreated group - offspring of nontreated females. The newborns were euthanized within the first 24 hours after birth and their hearts were removed and processed for histological study. Three fields per animal were considered for computer-assisted digital analysis and determination of the volume densities (Vv) of the nuclei and CM. The images were segmented with the aid of Image Pro PlusĀ® 4.5.029 software (Media Cybernetics). RESULTS: No difference was observed between the treated and nontreated groups in regard to body mass, cardiac mass, and the relation between cardiac and body mass. A significant reduction in the Vv[matrix] and a concomitant increase in the Vv[nuclei] were observed in the treated group as compared with those in the nontreated group. CONCLUSION: The treatment with enalapril of hypertensive rats during pregnancy alters the collagen content and structure of the myocardium of newborns

Topics: angiotensin, enalapril, collagen matrix, spontaneously hypertensive rats, Diseases of the circulatory (Cardiovascular) system, RC666-701
Publisher: Sociedade Brasileira de Cardiologia (SBC)
Year: 2003
OAI identifier: oai:doaj.org/article:74d32811b8094599bd70136ea149f79a
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1678-4170 (external link)
  • https://doaj.org/toc/0066-782X (external link)
  • http://www.scielo.br/scielo.ph... (external link)
  • https://doaj.org/article/74d32... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.