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Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication

By Marie Dujardin, Vanesa Madan, Neha Gandhi, Francois-Xavier Cantrelle, Hélène Launay, Isabelle Huvent, Ralf Bartenschlager, Guy Lippens and Xavier Hanoulle

Abstract

International audienc

Topics: [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics
Publisher: American Society for Biochemistry and Molecular Biology
Year: 2019
DOI identifier: 10.1074/jbc.RA119.009537
OAI identifier: oai:HAL:hal-02354947v1
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