An autosome-wide search using longitudinal data for loci linked to type 2 diabetes progression

Abstract

<p>Abstract</p> <p>A genome-wide screen was conducted for type 2 diabetes progression genes using measures of elevated fasting glucose levels as quantitative traits from the offspring enrolled in the Framingham Heart Study. We analyzed young (20–34 years) and old (≥ 35 years) subjects separately, using single-point and multipoint sibpair analysis, because of the possible differential impact of progression on the groups of interest. We observed significant linkage with change in fasting glucose levels on 1q25-32 (<it>p </it>= 5.21 × 10<sup>-8</sup>), 3p26.3-21.31 (<it>p </it>= 1 × 10<sup>-11</sup>), 8q23.1-24.13 (<it>p </it>= 2.94 × 10<sup>-6</sup>), 9p24.1-21.3 (<it>p </it>= 7 × 10<sup>-7</sup>), and 18p11.31-q22.1 (<it>p </it>< 10<sup>-11</sup>). The evidence for linkage on chromosomes 8 and 18 was consistent for the subset of study participants aged 43 through 55 years.</p

Similar works

Full text

thumbnail-image

Directory of Open Access Journals

Provided original full text link
oai:doaj.org/article:b67838a751cc486194dc09ec68daa003Last time updated on 12/17/2014

This paper was published in Directory of Open Access Journals.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.