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Survival analysis of 1148 women diagnosed with breast cancer in Southern Iran

By Abbas Rezaianzadeh, Janet Peacock, Daniel Reidpath, Abdolrasoul Talei, Seyed Vahid Hosseini and Davood Mehrabani

Abstract

Background: while there has been much research regarding risk factors and prognostic factors for breast cancer in general, research specific to Iran is sparse. Further, the association between breast cancer survival and socio-demographic and pathologic factors has been widely studied but the majority of these studies are from developed countries. Southern Iran has a population of approximately 4 million. To date, no research has been performed to determine breast cancer survival and to explore the association between the survival and socio-demographic and pathologic factors in Southern Iran, where this study was conducted.<br/>Methods: the data were obtained from the cancer registry in Fars province, Southern Iran and included 1148 women diagnosed with breast cancer between 2000 and 2005. The association between survival, and sociodemographic and pathological factors, distant metastasis at diagnosis, and treatment options was investigated using Cox regression.<br/>Results: the majority of patients were diagnosed with an advanced tumour size. Five-year overall survival was 58% (95%CI; 53%–62%). Cox regression showed that family income (good vs poor: hazard ratio 0.46, 95%CI; 0.23–0.90) smoking (HR = 1.40, 95%CI; 1.07–1.86), metastases to bone (HR = 2.25, 95%CI; 1.43–3.52) and lung (HR = 3.21, 95%CI;1.70–6.05), tumour size (? 2 cm vs ? 5 cm: HR = 2.07, 95%CI;1.39–3.09) and grade (poorly vs well differentiated HR = 2.33, 95%CI; 1.52– 3.37), lymph node ratio (0 vs 1: HR = 15.31, 95%CI; 8.89–26.33) and number of involved node (1 vs &gt;15: HR = 14.98, 95%CI; 8.83–25.33) were significantly related to survival.<br/>Conclusion: this is the first study to evaluate breast cancer survival in Southern Iran and has used a wide range of explanatory factors, 44. The results demonstrate that survival is relatively poor and is associated with diagnosis with late stage disease. We hypothesise that this is due to low level of awareness, lack of screening programs and subsequent late access to treatment

Topics: HT, RC0254
Year: 2009
OAI identifier: oai:eprints.soton.ac.uk:72758
Provided by: e-Prints Soton

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  1. (2003). Alagol H: Prognostic factors affecting survival and disease-free survival in lymph nodenegative breast carcinomas. J Surg Oncol doi
  2. (2001). C: Prognostic significance of local recurrence in breast cancer after postmastectomy radiotherapy. Strahlenther Onkol doi
  3. (2000). Callam MJ: Age-related variation in the treatment and outcomes of patients with breast carcinoma. Cancer doi
  4. (2003). CL: Diminished survival in patients with inner versus outer quadrant breast cancers. doi
  5. (2000). Clinical course and treatment results of breast cancer patients with ten or more positive axillary nodes. The Breast doi
  6. (2002). DM: Tumour location and prognostic characteristics as determinants of survival of women with invasive breast cancer: South Australian hospital-based cancer registries, 1987–1998. The Breast doi
  7. (2003). EA: Breast self-examination and death from breast cancer: a meta-analysis.
  8. (2004). European Concerted Action o n S u r v i v a l a n d C a r e o f C a n c e r P a t i e n t s doi
  9. (2001). Familial breast cancer: An investigation into the outcome of treatment for early stage disease. Fam Cancer
  10. (2001). Ferrarese F: Prognostic factors in breast cancer: The predictive value of the Nottingham prognostic index in patients with a long-term follow-up that were treated in a single institution. doi
  11. (2005). Goldhirsch A: Site of primary tumor has a prognostic role in operable breast cancer: The international breast cancer study group experience.
  12. (2002). Harirchi I: Breast self-examination: Knowledge, attitudes, and practices among female health care workers in Tehran, Iran. Breast J doi
  13. (2005). HR: Treatment results and prognostic factors of early breast cancer treated with a breast conserving operation and radiotherapy.
  14. (2004). Hryniuk W: Tree-based model for breast cancer prognostication.[see comment].
  15. (2004). Infiltrating lobular carcinoma of the breast: Tumor characteristics and clinical outcome. Breast Cancer Res
  16. (2003). Influence of tumor location on breast cancer prognosis. doi
  17. (2005). JM: Variation in survival after diagnosis of breast cancer in Switzerland. Ann Oncol
  18. (2002). Kazerooni T: Assessment of a breast cancer screening programme in Shiraz, Islamic Republic of Iran. East Mediterr Health J
  19. (2005). KB: Race is a fundamental prognostic indicator for 2325 northeastern Ohio women with infiltrating breast cancer. doi
  20. (2003). KI: Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer. Ann Surg doi
  21. (2003). Mamounas EP: Obesity, tamoxifen use, and outcomes in women with estrogen receptor-positive early-stage breast cancer.
  22. (2004). mass index as a prognostic feature in operable breast cancer: The international breast cancer study group experience. Ann Oncol
  23. (2004). Montazeri A: Breast cancer in Iran: A survival analysis. doi
  24. (2005). MP: Breast cancer survival in south Asian women in England and Wales. doi
  25. (2005). Obesity and outcomes in premenopausal and postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev
  26. (2004). Olivotto IA: Ten-year outcomes in a population-based cohort of node-negative, lymphatic, and vascular invasion-negative early breast cancers without adjuvant systemic therapies. doi
  27. (2005). Olivotto IA: The prognostic significance of the percentage of positive/dissected axillary lymph nodes in breast cancer recurrence and survival in patients with one to three positive axillary lymph nodes. Cancer doi
  28. (2005). Pearson AS: Effect of race on long-term survival of breast cancer patients: Transinstitutional analysis from an inner city hospital and university medical center. Am Surg
  29. (2004). Population-based survival from cancers of breast, cervix and ovary in women in
  30. (2002). Race socioeconomic status, and breast cancer treatment and survival. doi
  31. (2000). Rajaram SS: Middle Eastern Asian Islamic women and breast self-examination. Cancer Nurs doi
  32. (2006). Seddighi Z: Burden of breast cancer in Iran: A study of the Tehran population based cancer registry. Asian Pac J Cancer Prev
  33. (2005). Smoking and prognosis in women with breast cancer. doi
  34. (2005). Socio-economic factors and breast cancer survival – a populationbased cohort study (Sweden). Cancer Causes Control doi
  35. (2003). Socioeconomic factors and breast cancer in black and white Americans. Cancer Metastasis Rev
  36. (2004). Socioeconomic status and breast cancer survival in Pakistani women.
  37. (2000). Solin LJ: Relationship of family history and outcome after breast conservation therapy in women with ductal carcinoma in situ of the breast. doi
  38. (2004). South East Sweden Breast Cancer Group. Survival after treatment for breast cancer in a geographically defined population. doi
  39. (2003). Storme G: Functional form of the effect of the numbers of axillary nodes on survival in early breast cancer. doi
  40. (2004). Storme G: The lymph node ratio as prognostic factor in node-positive breast cancer. Radiother Oncol doi
  41. (2001). Strom E: Recursive partitioning analysis of locoregional recurrence patterns following mastectomy: Implications for adjuvant irradiation. doi
  42. (2009). Survival of women with breast cancer inBMC Cancer doi
  43. (2004). T: Does obesity compromise survival in women with breast cancer? The Breast doi
  44. (2005). Tan SM: Breast cancer in young Asian women: Study on survival. doi
  45. (2004). The impact of comorbidity on the survival of postmenopausal women with breast cancer. doi
  46. (2004). The outcome of treatment of breast cancer in a developing country – Oman. The Breast doi
  47. (2002). Tumor size, axillary lymph node status and steroid receptor expression in breast cancer: Prognostic relevance 5 years after surgery. Breast Cancer Research and Treatment doi
  48. (2005). years with primary breast carcinoma: Disease features at presentation. Cancer doi

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