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The Critical Role of Intrinsic Membrane Oscillations

By Sang-Hun Lee, Francisco Jose Urbano Suarez and Edgar Garcia Rill

Abstract

Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Because cortical circuits are incapable of maintaining high frequency activity in the gamma range for prolonged periods, those processes dependent on continuous gamma band activity are subserved by subthreshold oscillations. As such, intrinsic oscillations, coupled with synaptic circuits, are essential to prolonged maintenance of such functions as sensory perception and "binding", problem solving, memory, waking, and rapid eye movement (REM) sleep.Fil: Lee, Sang-Hun. Center For Translational Neuroscience; Estados UnidosFil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Garcia Rill, Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentin

Topics: BOTTOM-UP GAMMA, N-TYPE CHANNEL, P/Q-TYPE CHANNEL, PARAFASCICULAR NUCLEUS, PEDUNCULOPONTINE NUCLEUS, SUBCOERULEUS NUCLEUS, Neurociencias, Medicina Básica, CIENCIAS MÉDICAS Y DE LA SALUD
Publisher: Karger
Year: 2019
DOI identifier: 10.1159/000493900
OAI identifier: oai:ri.conicet.gov.ar:11336/89068
Provided by: CONICET Digital
Journal:

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