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Relationship between trait anxiety, prefrontal cortex, and attention bias to angry faces in children and adolescents

By Eva H. Telzer, Karin Mogg, Brendan P. Bradley, Xiaoqin Mai, Monique Ernst, Daniel S. Pine and Christopher S. Monk

Abstract

Using event-related functional magnetic resonance imaging (fMRI) with a visual-probe task that<br/>assesses attention to threat, we investigated the cognitive and neurophysiological correlates of trait<br/>anxiety in youth. During fMRI acquisition, 16 healthy children and adolescents viewed angry-neutral<br/>face pairs and responded to a probe that was on the same (angry-congruent) or opposite (angryincongruent)<br/>side as the angry face. Attention bias scores were calculated by subtracting participants’<br/>mean reaction time for angry-congruent trials from angry-incongruent trials. Trait anxiety was<br/>positively associated with attention bias towards angry faces. Neurophysiologically, trait anxiety was<br/>positively associated with right dorsolateral prefrontal cortex (PFC) activation on a contrast of trials<br/>that reflect the attention bias for angry faces (i.e., angry-incongruent versus angry-congruent trials).<br/>Trait anxiety was also positively associated with right ventrolateral PFC activation on trials with face<br/>stimuli (versus baseline), irrespective of their emotional content

Topics: BF
Year: 2008
OAI identifier: oai:eprints.soton.ac.uk:145983
Provided by: e-Prints Soton
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