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Incorporating household structure into a discrete event simulation model of tuberculosis and HIV

By G.R. Mellor, C.S.M. Currie and E.L. Corbett

Abstract

Human immunodeficiency virus (HIV) increases the risks of developing tuberculosis (TB) disease following<br/>infection, and speeds up disease progression. This has had a devastating effect on TB epidemics in sub-Saharan<br/>Africa, where incidence rates have more than trebled in the past twenty years. Current control methods for TB<br/>disease have failed to keep pace with this growth in TB, and there is an urgent need to find TB control strategies<br/>that are effective in high-HIV prevalent settings. This paper describes a discrete-event simulation model of<br/>endemic TB that includes the effects of HIV and of household structure on the transmission dynamics of TB.<br/>Incorporating a social structure allows us to compare the effectiveness of contact-tracing interventions with<br/>targeted case-finding at high risk groups. We describe the modeling of the household structure in some detail, as<br/>this has applications to the modeling of other infectious diseases

Topics: QA, RA0421, RB
Year: 2011
OAI identifier: oai:eprints.soton.ac.uk:156177
Provided by: e-Prints Soton
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