Hydroxylation reactions catalysed using P450 enzymes have a range of applications in drug metabolite production and lead diversification Facilitating the identification of toxic metabolites early in the drug development process and enabling the diversification of lead compounds through the generation of a broad range of hydroxylated derivatives may lead to the discovery of safer, more potent drugs with a reduced risk of failure in clinical trials. In humans and animals most xenobiotic compounds including drugs are metabolised and eliminated via a reaction sequence carried out predominantly in the liver. 1 Commonly in drug metabolism the first ste

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